Recombination factors of Saccharomyces cerevisiae

Patrick Sung, Kelly Miguel Trujillo, Stephen Van Komen

Research output: Contribution to journalReview article

153 Scopus citations

Abstract

The budding yeast Saccharomyces cerevisiae has been an excellent genetic and biochemical model for our understanding of homologous recombination. Central to the process of homologous recombination are the products of the RAD52 epistasis group of genes, whose functions we now know include the nucleolytic processing of DNA double-stand breaks, the ability to conduct a DNA homology search, and the capacity to promote the exchange of genetic information between homologous regions on recombining chromosomes. It is also clear that the basic functions of the RAD52 group of genes have been highly conserved among eukaryotes. Disruption of this important process causes genomic instability, which can result in a number of unsavory consequences, including tumorigenesis and cell death. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)257-275
Number of pages19
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume451
Issue number1-2
DOIs
StatePublished - Jun 30 2000

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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