Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide

Troy Wiegand; Jeremy Karr; Jay D. Steinkruger; Kris Hiebner; Bobby Simetich; Mark Beatty; Jody Redepenning

doi:10.1021/cm800895r

Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide

Troy Wiegand, Jeremy Karr, Jay D. Steinkruger, Kris Hiebner, Bobby Simetich, Mark Beatty, Jody Redepenning

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10 Scopus citations

Abstract

Polymerization of L-lactide within the pores of anorganic mammalian bone is described. No additional solvent or catalyst is used. The resulting composites exhibit macroscopic morphologies and mechanical properties similar to that of the original bone. We observe an average compressive strength of 194 MPa and an elastic modulus of 8.8 GPa for composites comprised of poly-L-lactide and anorganic bone derived from bovine femurs. Modeling of the reaction kinetics with synthetic sources of crystalline hydroxyapatite powder suggests that polymerization proceeds via a surface-initiated mechanism that is first order in surface area of hydroxyapatite and first order in mole fraction of L-lactide.

Original language	English (US)
Pages (from-to)	5016-5022
Number of pages	7
Journal	Chemistry of Materials
Volume	20
Issue number	15
DOIs	https://doi.org/10.1021/cm800895r
State	Published - Aug 12 2008

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Materials Chemistry

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abstract = "Polymerization of L-lactide within the pores of anorganic mammalian bone is described. No additional solvent or catalyst is used. The resulting composites exhibit macroscopic morphologies and mechanical properties similar to that of the original bone. We observe an average compressive strength of 194 MPa and an elastic modulus of 8.8 GPa for composites comprised of poly-L-lactide and anorganic bone derived from bovine femurs. Modeling of the reaction kinetics with synthetic sources of crystalline hydroxyapatite powder suggests that polymerization proceeds via a surface-initiated mechanism that is first order in surface area of hydroxyapatite and first order in mole fraction of L-lactide.",

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AU - Wiegand, Troy

AU - Karr, Jeremy

AU - Steinkruger, Jay D.

AU - Hiebner, Kris

AU - Simetich, Bobby

AU - Beatty, Mark

AU - Redepenning, Jody

PY - 2008/8/12

Y1 - 2008/8/12

N2 - Polymerization of L-lactide within the pores of anorganic mammalian bone is described. No additional solvent or catalyst is used. The resulting composites exhibit macroscopic morphologies and mechanical properties similar to that of the original bone. We observe an average compressive strength of 194 MPa and an elastic modulus of 8.8 GPa for composites comprised of poly-L-lactide and anorganic bone derived from bovine femurs. Modeling of the reaction kinetics with synthetic sources of crystalline hydroxyapatite powder suggests that polymerization proceeds via a surface-initiated mechanism that is first order in surface area of hydroxyapatite and first order in mole fraction of L-lactide.

AB - Polymerization of L-lactide within the pores of anorganic mammalian bone is described. No additional solvent or catalyst is used. The resulting composites exhibit macroscopic morphologies and mechanical properties similar to that of the original bone. We observe an average compressive strength of 194 MPa and an elastic modulus of 8.8 GPa for composites comprised of poly-L-lactide and anorganic bone derived from bovine femurs. Modeling of the reaction kinetics with synthetic sources of crystalline hydroxyapatite powder suggests that polymerization proceeds via a surface-initiated mechanism that is first order in surface area of hydroxyapatite and first order in mole fraction of L-lactide.

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Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide

Abstract

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