Reconstruction of Pathways Associated with Amino Acid Metabolism in Human Mitochondria

Purnima Guda, Chittibabu Guda, Shankar Subramaniam

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We have used a bioinformatics approach for the identification and reconstruction of metabolic pathways associated with amino acid metabolism in human mitochondria. Human mitochondrial proteins determined by experimental and computational methods have been superposed on the reference pathways from the KEGG database to identify mitochondrial pathways. Enzymes at the entry and exit points for each reconstructed pathway were identified, and mitochondrial solute carrier proteins were determined where applicable. Intermediate enzymes in the mitochondrial pathways were identified based on the annotations available from public databases, evidence in current literature, or our MITOPRED program, which predicts the mitochondrial localization of proteins. Through integration of the data derived from experimental, bibliographical, and computational sources, we reconstructed the amino acid metabolic pathways in human mitochondria, which could help better understand the mitochondrial metabolism and its role in human health.

Original languageEnglish (US)
Pages (from-to)166-176
Number of pages11
JournalGenomics, Proteomics and Bioinformatics
Volume5
Issue number3-4
DOIs
StatePublished - Mar 1 2007

Keywords

  • amino acid metabolism
  • human
  • metabolic pathways
  • mitochondria

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Computational Mathematics

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