Recovery of 2,3-Butanediol by Vacuum Membrane Distillation

N. Qureshi, M. M. Meagher, R. W. Hutkins

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


A vacuum membrane distillation process using a microporous polytetrafluoroethylene (PTFE) membrane was developed to concentrate 2,3-butanediol from model 2,3-butanediol solutions and fermentation broths. A 0.22-μm PTFE membrane passed water vapor while retaining 2,3-butanediol. Water flux through the membrane was 4 kg/m2·h at 35°C and 12-14 kg/m2·h at 55°C. Medium components, especially yeast extract and fermentation broth, reduced flux as compared to model solutions. Using this process, butanediol was concentrated from 40 g/L to about 650 g/L in the model solution, and when integrated to a fed-batch reactor, 2,3-butanediol was concentrated to over 430 g/L.

Original languageEnglish (US)
Pages (from-to)1733-1748
Number of pages16
JournalSeparation Science and Technology
Issue number13
StatePublished - Aug 1 1994


  • 2,3-Butanediol
  • Fermentation
  • Recovery
  • Vacuum membrane distillation

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Process Chemistry and Technology
  • Filtration and Separation


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