Recurrence following Resection of Intraductal Papillary Mucinous Neoplasms: A Systematic Review to Guide Surveillance

Aneesa Salahuddin, Varna Thayaparan, Ahmad Hamad, Willi Tarver, Jordan M. Cloyd, Alex C. Kim, Robyn Gebhard, Timothy M. Pawlik, Bradley N. Reames, Aslam Ejaz

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Patients who undergo resection for non-invasive IPMN are at risk for long-term recurrence. Further evidence is needed to identify evidence-based surveillance strategies based on the risk of recurrence. We performed a systematic review of the current literature regarding recurrence patterns following resection of non-invasive IPMN to summarize evidence-based recommendations for surveillance. Among the 61 studies reviewed, a total of 8779 patients underwent resection for non-invasive IPMN. The pooled overall median follow-up time was 49.5 months (IQR: 38.5–57.7) and ranged between 14.1 months and 114 months. The overall median recurrence rate for patients with resected non-invasive IPMN was 8.8% (IQR: 5.0, 15.6) and ranged from 0% to 27.6%. Among the 33 studies reporting the time to recurrence, the overall median time to recurrence was 24 months (IQR: 17, 46). Existing literature on recurrence rates and post-resection surveillance strategies for patients with resected non-invasive IPMN varies greatly. Patients with resected non-invasive IPMN appear to be at risk for long-term recurrence and should undergo routine surveillance.

Original languageEnglish (US)
Article number830
JournalJournal of Clinical Medicine
Volume13
Issue number3
DOIs
StatePublished - Feb 2024

Keywords

  • IPMN
  • follow-up
  • pancreas cyst
  • pancreatectomy
  • pancreatic cystic neoplasm
  • progression
  • recurrence-free survival

ASJC Scopus subject areas

  • General Medicine

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