Recurrent anomalies of 6q25 in chondromyxoid fibroma

Aida Safar, Marilu Nelson, James R. Neff, Gerhard E. Maale, Jane Bayani, Jeremy Squire, Julia A. Bridge

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondromyxoid fibroma may be difficult to distinguish from other cartilaginous neoplasms. Recently, a pericentric inversion of chromosome 6 [inv(6)(p25q13)] has been proposed as a specific genetic marker for chondromyxoid fibroma. In this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoid fibroma cases showed clonal abnormalities of chromosome 6 but at a breakpoint on the long arm (q25) distal to that described in the pericentric inversion. These findings suggest that several distinct breakpoints on chromosome 6 are nonrandomly involved in chondromyxoid fibroma. (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)306-311
Number of pages6
JournalHuman Pathology
Volume31
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Chondromyxoid fibroma
  • Cytogenetics
  • Spectral karyotyping

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Safar, A., Nelson, M., Neff, J. R., Maale, G. E., Bayani, J., Squire, J., & Bridge, J. A. (2000). Recurrent anomalies of 6q25 in chondromyxoid fibroma. Human Pathology, 31(3), 306-311. https://doi.org/10.1016/S0046-8177(00)80243-9