@article{6f7a4b11190f48feaa82cf0379405ba0,
title = "Recurrent anomalies of 6q25 in chondromyxoid fibroma",
abstract = "Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondromyxoid fibroma may be difficult to distinguish from other cartilaginous neoplasms. Recently, a pericentric inversion of chromosome 6 [inv(6)(p25q13)] has been proposed as a specific genetic marker for chondromyxoid fibroma. In this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoid fibroma cases showed clonal abnormalities of chromosome 6 but at a breakpoint on the long arm (q25) distal to that described in the pericentric inversion. These findings suggest that several distinct breakpoints on chromosome 6 are nonrandomly involved in chondromyxoid fibroma. (C) 2000 by W.B. Saunders Company.",
keywords = "Chondromyxoid fibroma, Cytogenetics, Spectral karyotyping",
author = "Aida Safar and Marilu Nelson and Neff, {James R.} and Maale, {Gerhard E.} and Jane Bayani and Jeremy Squire and Bridge, {Julia A.}",
note = "Funding Information: From the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; the Department of Orthopaedic Surgery, University of Nebraska Medical Center, Omaha, NE; the Department of Orthopaedic Surgery, Presbyterian Hospital, Dallas, TX; the Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; and the Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE. Accepted for publication November 8, 1999. Supported in part by grants from the Nebraska State Department of Health, LB595, and the John A. Wiebe Children's Health Care Fund. Address correspondence and reprint requests to Julia A. Bridge, MD, Department of Pathology/Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135. Copyright {\textcopyright} 2000 by W.B. Saunders Company 0046-8177/00/3103-0007510.00/0 doi: 10.1053/hp.2000.5228",
year = "2000",
doi = "10.1016/S0046-8177(00)80243-9",
language = "English (US)",
volume = "31",
pages = "306--311",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders",
number = "3",
}