Recurrent pump thrombosis is common after axial continuous-flow left ventricular assist device exchange

Marian Urban, John Um, Michael Moulton, Douglas Stoller, Ronald Zolty, Brian Lowes, Collin Macdonald, Natalia McCain, Aleem Siddique

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In selected patients with left ventricular assist device–associated infection or malfunction, pump exchange may become necessary after conservative treatment options fail and heart transplantation is not readily available. We examined the survival and complication rate in patients (⩾19 years of age) who underwent HeartMate II to HeartMate II exchange at our institution from 1 January 2010 to 28 February 2018. Clinical outcomes were analyzed and compared for patients who underwent exchange for pump thrombosis (14 patients), breach of driveline integrity (5 patients), and device-associated infection (2 patients). There were no differences in 30-day mortality (p = 0.58), need for temporary renal replacement therapy (p = 0.58), right ventricular mechanical support (p = 0.11), and postoperative stroke (p = 0.80) among groups. Survival at 1 year was 90% ± 7% for the whole cohort and 85% ± 10% for those who underwent exchange for pump thrombosis. In patients exchanged for device thrombosis, freedom from re-thrombosis and survival free from pump re-thrombosis at 1 year were 49% ± 16% and 42% ± 15%, respectively. No association of demographic and clinical variables with the risk of recurrent pump thrombosis after the first exchange was identified. Survival after left ventricular assist device exchange compares well with published results after primary left ventricular assist device implantation. However, recurrence of thrombosis was common among patients who required a left ventricular assist device exchange due to pump thrombosis. In this sub-group, consideration should be given to alternative strategies to improve the outcomes.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalInternational Journal of Artificial Organs
Volume43
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • Blood pump
  • axial flow
  • centrifugal flow
  • circulatory support
  • extracorporeal life support
  • ventricular assist device

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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