TY - GEN
T1 - Red cell damage in flexible leaflet heart valves
AU - Liu, Y.
AU - Aluri, S.
AU - Richenbacher, W.
AU - Chandran, K. B.
PY - 1999
Y1 - 1999
N2 - A pyrolyric carbon (rigid) bileaflet mechanical valve and an ultra high molecular weight polyethylene (UHMPE - flexible) tilting disc valves were used in the study in an in vitro pulsatile flow loop. Fresh bovine blood was used as the blood analog fluid and plasma free hemoglobin (PFHg: a measure of hemolysis) measured at 15 min. intervals, normalized to magnitude at the start of the experiment, was used as an index for blood damage. The negative pressure transients in the atrial side of the chamber were also measured. The mean and standard deviations of eight valves in each category were computed. The blood losses as well as the negative pressure transients with the flexible leaflet valve were significantly lower compared to the rigid leaflet valve. The flexibility of the leaflet, and the reduction in water hammer effect at the instant of valve closure results in reduced damage to blood cells and may be an important factor in mechanical valve design.
AB - A pyrolyric carbon (rigid) bileaflet mechanical valve and an ultra high molecular weight polyethylene (UHMPE - flexible) tilting disc valves were used in the study in an in vitro pulsatile flow loop. Fresh bovine blood was used as the blood analog fluid and plasma free hemoglobin (PFHg: a measure of hemolysis) measured at 15 min. intervals, normalized to magnitude at the start of the experiment, was used as an index for blood damage. The negative pressure transients in the atrial side of the chamber were also measured. The mean and standard deviations of eight valves in each category were computed. The blood losses as well as the negative pressure transients with the flexible leaflet valve were significantly lower compared to the rigid leaflet valve. The flexibility of the leaflet, and the reduction in water hammer effect at the instant of valve closure results in reduced damage to blood cells and may be an important factor in mechanical valve design.
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M3 - Conference contribution
AN - SCOPUS:0033310678
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 763
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -