Redox homeostasis, oxidative stress and mitophagy

Carla Garza-Lombó, Aglaia Pappa, Mihalis I. Panayiotidis, Rodrigo Franco

Research output: Contribution to journalReview article

Abstract

Autophagy is a ubiquitous homeostatic mechanism for the degradation or turnover of cellular components. Degradation of mitochondria via autophagy (mitophagy) is involved in a number of physiological processes including cellular homeostasis, differentiation and aging. Upon stress or injury, mitophagy prevents the accumulation of damaged mitochondria and the increased steady state levels of reactive oxygen species leading to oxidative stress and cell death. A number of human diseases, particularly neurodegenerative disorders, have been linked to the dysregulation of mitophagy. In this mini-review, we aimed to review the molecular mechanisms involved in the regulation of mitophagy and their relationship with redox signaling and oxidative stress.

Original languageEnglish (US)
Pages (from-to)105-117
Number of pages13
JournalMitochondrion
Volume51
DOIs
StatePublished - Mar 2020

Keywords

  • Autophagy
  • Fission
  • Fusion
  • Mitochondrial dynamics

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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