Redox signaling in central neural regulation of cardiovascular function

Matthew C. Zimmerman, Robin L. Davisson

Research output: Contribution to journalReview article

97 Scopus citations

Abstract

One of the most prominent concepts to emerge in cardiovascular research over the past decade, especially in areas focused on angiotensin II (AngII), is that reactive oxygen species (ROS) are critical signaling molecules in a wide range of cellular processes. Many of the physiological effects of AngII are mediated by ROS, and alterations in AngII-mediated redox mechanisms are implicated in cardiovascular diseases such as hypertension and atherosclerosis. Although most investigations to date have focused on the vasculature as a key player, the nervous system has recently begun to gain attention in this field. Accumulating evidence suggests that ROS have important effects on central neural mechanisms involved in blood pressure regulation, volume homeostasis, and autonomic function, particularly those that involve AngII signaling. Furthermore, oxidant stress in the central nervous system is implicated in the neuro-dysregulation associated with some forms of hypertension and heart failure. The main objective of this review is to discuss the recent progress and prospects for this new field of central redox signaling in cardiovascular regulation, while also addressing the molecular tools that have spurred it forward.

Original languageEnglish (US)
Pages (from-to)125-149
Number of pages25
JournalProgress in Biophysics and Molecular Biology
Volume84
Issue number2-3
DOIs
StatePublished - Jan 1 2004

Keywords

  • CNS
  • Free radicals
  • NAD(P)H oxidase
  • Renin-angiotensin system
  • Superoxide dismutase

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology

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