Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Richard L. O'Sullivan; Scott L. Rauch; Hans C. Breiter; Igor D. Grachev; Lee Baer; David N. Kennedy; Nancy J. Keuthen; Cary R. Savage; Peter A. Manzo; Verne S. Caviness; Michael A. Jenike

doi:10.1016/S0006-3223(96)00297-1

Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Richard L. O'Sullivan, Scott L. Rauch, Hans C. Breiter, Igor D. Grachev, Lee Baer, David N. Kennedy, Nancy J. Keuthen, Cary R. Savage, Peter A. Manzo, Verne S. Caviness, Michael A. Jenike

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

Original language	English (US)
Pages (from-to)	39-45
Number of pages	7
Journal	Biological Psychiatry
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/S0006-3223(96)00297-1
State	Published - Jul 1 1997
Externally published	Yes

Keywords

Basal ganglia
Morphometric magnetic resonance imaging
Trichotillomania
putamen

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/S0006-3223(96)00297-1

Cite this

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title = "Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging",

abstract = "A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.",

keywords = "Basal ganglia, Morphometric magnetic resonance imaging, Trichotillomania, putamen",

author = "O'Sullivan, {Richard L.} and Rauch, {Scott L.} and Breiter, {Hans C.} and Grachev, {Igor D.} and Lee Baer and Kennedy, {David N.} and Keuthen, {Nancy J.} and Savage, {Cary R.} and Manzo, {Peter A.} and Caviness, {Verne S.} and Jenike, {Michael A.}",

year = "1997",

month = jul,

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doi = "10.1016/S0006-3223(96)00297-1",

language = "English (US)",

volume = "42",

pages = "39--45",

journal = "Biological Psychiatry",

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T1 - Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

AU - O'Sullivan, Richard L.

AU - Rauch, Scott L.

AU - Breiter, Hans C.

AU - Grachev, Igor D.

AU - Baer, Lee

AU - Kennedy, David N.

AU - Keuthen, Nancy J.

AU - Savage, Cary R.

AU - Manzo, Peter A.

AU - Caviness, Verne S.

AU - Jenike, Michael A.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

AB - A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

KW - Basal ganglia

KW - Morphometric magnetic resonance imaging

KW - Trichotillomania

KW - putamen

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JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 1

ER -

Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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