Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Richard L. O'Sullivan, Scott L. Rauch, Hans C. Breiter, Igor D. Grachev, Lee Baer, David N. Kennedy, Nancy J. Keuthen, Cary R. Savage, Peter A. Manzo, Verne S. Caviness, Michael A. Jenike

Research output: Contribution to journalArticle

137 Scopus citations

Abstract

A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalBiological Psychiatry
Volume42
Issue number1
DOIs
StatePublished - Jul 1 1997

Keywords

  • Basal ganglia
  • Morphometric magnetic resonance imaging
  • Trichotillomania
  • putamen

ASJC Scopus subject areas

  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging'. Together they form a unique fingerprint.

  • Cite this

    O'Sullivan, R. L., Rauch, S. L., Breiter, H. C., Grachev, I. D., Baer, L., Kennedy, D. N., Keuthen, N. J., Savage, C. R., Manzo, P. A., Caviness, V. S., & Jenike, M. A. (1997). Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. Biological Psychiatry, 42(1), 39-45. https://doi.org/10.1016/S0006-3223(96)00297-1