Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells

Xuesong Gu, Luiz F. Zerbini, Hasan H. Otu, Manoj Bhasin, Quanli Yang, Marie G. Joseph, Franck Grall, Tomi Onatunde, Ricardo G. Correa, Towia A. Libermann

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

The epithelium-specific Ets transcription factor, PDEF, plays a role in prostate and breast cancer, although its precise function has not been established. In prostate cancer, PDEF is involved in regulating prostate-specific antigen expression via interaction with the androgen receptor and NKX3.1, and down-regulation of PDEF by antiproliferative agents has been associated with reduced PDEF expression. We now report that reduced expression of PDEF leads to a morphologic change, increased migration and invasiveness in prostate cancer cells, reminiscent of transforming growth factor β (TGFβ) function and epithelial-to-mesenchyntal transition. Indeed, inhibition of PDEF expression triggers a transcriptional program of genes involved in the TGFβ pathway, migration, invasion, adhesion, and epithelial dedifferentiation. Our results establish PDEF as a critical regulator of genes involved in cell motility, invasion, and adhesion of prostate cancer cells.

Original languageEnglish (US)
Pages (from-to)4219-4226
Number of pages8
JournalCancer Research
Volume67
Issue number9
DOIs
StatePublished - May 1 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Gu, X., Zerbini, L. F., Otu, H. H., Bhasin, M., Yang, Q., Joseph, M. G., Grall, F., Onatunde, T., Correa, R. G., & Libermann, T. A. (2007). Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells. Cancer Research, 67(9), 4219-4226. https://doi.org/10.1158/0008-5472.CAN-06-3689