Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFα inhibitor in SCID mice with HIV-1 encephalitis

Y. Persidsky, J. Limoges, J. Rasmussen, J. Zheng, A. Gearing, H. E. Gendelman

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

The effects of anti-inflammatory drugs on glial immunity and neuropathology were determined in a severe combined immune deficiency (SCID) mouse model of HIV-1 encephalitis. HIV-1-infected human monocyte-derived macrophages (MDM) are stereotactically inoculated into basal ganglia resulting in a multinucleated giant cell encephalitis. A platelet activating factor antagonist and a matrix metalloproteinase inhibitor, which also inhibits tumor necrosis factor alpha release, were administered to animals at the time of the MDM inoculation. The drugs administered in combination markedly reduced brain inflammation, astrogliosis and microglia activation. These findings demonstrate that reduction of brain inflammatory responses, independent of viral replication, can affect HIVE pathology in an animal model system of disease.

Original languageEnglish (US)
Pages (from-to)57-68
Number of pages12
JournalJournal of Neuroimmunology
Volume114
Issue number1-2
DOIs
StatePublished - Mar 1 2001

Keywords

  • Anti-inflammatory drugs
  • HIV-1 encephalitis
  • Mononuclear phagocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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