TY - JOUR
T1 - Reflections on MUC1 glycoprotein
T2 - the hidden potential of isoforms in carcinogenesis
AU - Sousa, Andreia M.
AU - Grandgenett, Paul M.
AU - David, Leonor
AU - Almeida, Raquel
AU - Hollingsworth, Michael Anthony
AU - Santos-Silva, Filipe
N1 - Publisher Copyright:
© 2016 APMIS. Published by John Wiley & Sons Ltd
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Mucin 1 (MUC1) has been described as the renaissance molecule due to the large set of functions it displays in both normal and neoplastic cells. This membrane-tethered glycoprotein is overexpressed and aberrantly glycosylated in most epithelial cancers, being involved in several processes related with malignant phenotype acquisition. With a highly polymorphic structure, both in the polypeptide and glycan counterparts, MUC1 variability has been associated with susceptibility to several diseases, including cancer. Biochemical features and biological functions have been characterized upon the full-length MUC1 protein, remaining to clarify the real impact on cell dynamics of the plethora of MUC1 isoforms. This review aims to encompass a detailed characterization of MUC1 role in carcinogenesis, highlighting recent findings in cell differentiation and uncovering new evidences of MUC1 isoforms involvement in malignant phenotype.
AB - Mucin 1 (MUC1) has been described as the renaissance molecule due to the large set of functions it displays in both normal and neoplastic cells. This membrane-tethered glycoprotein is overexpressed and aberrantly glycosylated in most epithelial cancers, being involved in several processes related with malignant phenotype acquisition. With a highly polymorphic structure, both in the polypeptide and glycan counterparts, MUC1 variability has been associated with susceptibility to several diseases, including cancer. Biochemical features and biological functions have been characterized upon the full-length MUC1 protein, remaining to clarify the real impact on cell dynamics of the plethora of MUC1 isoforms. This review aims to encompass a detailed characterization of MUC1 role in carcinogenesis, highlighting recent findings in cell differentiation and uncovering new evidences of MUC1 isoforms involvement in malignant phenotype.
KW - MUC1
KW - MUC1 splice variants
KW - cancer
KW - cell differentiation
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U2 - 10.1111/apm.12587
DO - 10.1111/apm.12587
M3 - Review article
C2 - 27538373
AN - SCOPUS:84982306248
SN - 0903-4641
VL - 124
SP - 913
EP - 924
JO - APMIS
JF - APMIS
IS - 11
ER -