Regiões do cérebro relacionadas à melhora da memória verbal em idosos saudáveis

Translated title of the contribution: Brain regions supporting verbal memory improvement in healthy older subjects

Eliane C. Miotto, Joana B. Balardin, Cary R. Savage, Maria da Graça M. Martin, Marcelo C. Batistuzzo, Edson Amaro Junior, Ricardo Nitrini

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Despite growing interest in developing cognitive training interventions to minimize the aging cognitive decline process, no studies have attempted to explore which brain regions support the application of semantic strategies during verbal memory encoding. Our aim was to investigate the behavioral performance and brain correlates of these strategies in elderly individuals using fMRI in healthy older subjects.

Method: Subjects were scanned twice on the same day, before and after, directed instructions to apply semantic strategies during the encoding of word lists.

Results: Improved memory performance associated to increased semantic strategy application and brain activity in the left inferior and middle and right medial superior prefrontal cortex were found after the directed instructions. There was also reduced activation in areas related to strategy mobilization.

Conclusion: Improved memory performance in older subjects after the application of semantic strategies was associated with functional brain reorganization involving regions inside and outside the typical memory network.

Translated title of the contributionBrain regions supporting verbal memory improvement in healthy older subjects
Original languagePortuguese
Pages (from-to)663-670
Number of pages8
JournalArquivos de Neuro-Psiquiatria
Issue number9
StatePublished - Sep 1 2014
Externally publishedYes


  • #fMRI
  • Episodic memory
  • Older subjects
  • Semantic strategies

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry


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