Regional multiaxial mechanical properties of the porcine anterior lens capsule

G. David, R. M. Pedrigi, M. R. Heistand, J. D. Humphrey

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The lens capsule of the eye plays fundamental biomechanical roles in both normal physiological processes and clinical interventions. There has been modest attention given to the mechanical properties of this important membrane, however, and prior studies have focused on 1-D analyses of the data. We present results that suggest that the porcine anterior lens capsule has a complex, regionally dependent, nonlinear, anisotropic behavior. Specifically, using a subdomain inverse finite element method to analyze data collected via a new biplane video-based test system, we found that the lens capsule is nearly isotropic (in-plane) near the pole but progressively stiffer in the circumferential compared to the meridional direction as one approaches the equator. Because the porcine capsule is a good model of the young human capsule, there is strong motivation to determine if similar regional variations exist in the human lens capsule for knowledge of such complexities may allow us to improve the design of surgical procedures and implants.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalJournal of Biomechanical Engineering
Volume129
Issue number1
DOIs
StatePublished - Feb 2007

Keywords

  • Accommodation
  • Biomechanics
  • Cataracts
  • Stiffness
  • Stress

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

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