TY - GEN
T1 - Regional responses of rat brain to impactor parameters
AU - Hua, Yi
AU - Akula, Praveen
AU - Kelso, Matthew
AU - Gu, Linxia
N1 - Publisher Copyright:
© Copyright 2015 by ASME.
PY - 2015
Y1 - 2015
N2 - The closed head impact (CHI) rat models are commonly used for studying the traumatic brain injury. Although various impact parameters (e.g., impact depth, velocity, and position) have been investigated by a number of researchers, little is known about the effects of the impactor shape, diameter, and material on the internal responses of the rat brain. In this work, numerical CHI experiments were conducted to investigate the sensitivities of intracranial responses to the impactor details such as impactor shape, diameter, and material. A 3D finite element rat head model with anatomical details was subjected to impact loadings. Results revealed that the impactor shape can affect the intracranial responses significantly. The effect of impactor diameter on the intracranial responses in different brain regions was uniform. In addition, careful attention should be paid when using an extremely compliant material for the impactor, since the actual impact depth might be compensated by the impactor deformation.
AB - The closed head impact (CHI) rat models are commonly used for studying the traumatic brain injury. Although various impact parameters (e.g., impact depth, velocity, and position) have been investigated by a number of researchers, little is known about the effects of the impactor shape, diameter, and material on the internal responses of the rat brain. In this work, numerical CHI experiments were conducted to investigate the sensitivities of intracranial responses to the impactor details such as impactor shape, diameter, and material. A 3D finite element rat head model with anatomical details was subjected to impact loadings. Results revealed that the impactor shape can affect the intracranial responses significantly. The effect of impactor diameter on the intracranial responses in different brain regions was uniform. In addition, careful attention should be paid when using an extremely compliant material for the impactor, since the actual impact depth might be compensated by the impactor deformation.
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U2 - 10.1115/DETC2015-47373
DO - 10.1115/DETC2015-47373
M3 - Conference contribution
AN - SCOPUS:84978943570
T3 - Proceedings of the ASME Design Engineering Technical Conference
BT - 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015
Y2 - 2 August 2015 through 5 August 2015
ER -