Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain

Le Don Bean; Hong Zheng; Kaushik P. Patel; Daniel T. Monaghan

doi:10.1016/j.brainres.2006.07.090

Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain

Le Don Bean, Hong Zheng, Kaushik P. Patel, Daniel T. Monaghan

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Insulin insufficiency has multiple actions on the CNS. Three weeks after streptozotocin-induced diabetes in rats, we found a preferential downregulation of l-[³H]glutamate-labeled NMDA receptors in primary sensory cortical regions. Layers I-III of the parietal cortex and superficial piriform cortex were the most sensitive followed by other cortical regions and, in turn, deeper brain structures. These effects on NMDA receptors can potentially explain some of the known CNS effects of diabetes.

Original language	English (US)
Pages (from-to)	217-222
Number of pages	6
Journal	Brain Research
Volume	1115
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2006.07.090
State	Published - Oct 18 2006

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2006.07.090

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Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain

Abstract

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