TY - JOUR
T1 - Regulating the intersection of metabolism and pathogenesis in gram-positive bacteria
AU - Richardson, Anthony R.
AU - Somerville, Greg A.
AU - Sonenshein, Abraham L.
N1 - Funding Information:
G.A.S. was supported by funds provided through the Hatch Act to the University of Nebraska Institute of Agriculture and Natural Resources and by funds provided through the National Institutes of Health (R01AI087668). Unpublished work from the A.L.S. laboratory was supported by a grant (R01GM042219) from the National Institutes of Health. A.R.R. was supported by funds provided through the National Institutes of Health (R01AI093613).
Publisher Copyright:
© 2014 American Society for Microbiology.
PY - 2015
Y1 - 2015
N2 - Pathogenic bacteria must contend with immune systems that actively restrict the availability of nutrients and cofactors, and create a hostile growth environment. To deal with these hostile environments, pathogenic bacteria have evolved or acquired virulence determinants that aid in the acquisition of nutrients. This connection between pathogenesis and nutrition may explain why regulators of metabolism in nonpathogenic bacteria are used by pathogenic bacteria to regulate both metabolism and virulence. Such coordinated regulation is presumably advantageous because it conserves carbon and energy by aligning synthesis of virulence determinants with the nutritional environment. In Gram-positive bacterial pathogens, at least three metabolite-responsive global regulators, CcpA, CodY, and Rex, have been shown to coordinate the expression of metabolism and virulence genes. In this chapter, we discuss how environmental challenges alter metabolism, the regulators that respond to this altered metabolism, and how these regulators influence the host-pathogen interaction.
AB - Pathogenic bacteria must contend with immune systems that actively restrict the availability of nutrients and cofactors, and create a hostile growth environment. To deal with these hostile environments, pathogenic bacteria have evolved or acquired virulence determinants that aid in the acquisition of nutrients. This connection between pathogenesis and nutrition may explain why regulators of metabolism in nonpathogenic bacteria are used by pathogenic bacteria to regulate both metabolism and virulence. Such coordinated regulation is presumably advantageous because it conserves carbon and energy by aligning synthesis of virulence determinants with the nutritional environment. In Gram-positive bacterial pathogens, at least three metabolite-responsive global regulators, CcpA, CodY, and Rex, have been shown to coordinate the expression of metabolism and virulence genes. In this chapter, we discuss how environmental challenges alter metabolism, the regulators that respond to this altered metabolism, and how these regulators influence the host-pathogen interaction.
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U2 - 10.1128/microbiolspec.MBP-0004-2014
DO - 10.1128/microbiolspec.MBP-0004-2014
M3 - Article
C2 - 26185086
AN - SCOPUS:84958005155
VL - 3
JO - Microbiology spectrum
JF - Microbiology spectrum
SN - 2165-0497
IS - 3
M1 - MBP-0004-2014
ER -