Regulation of B cell tolerance by murine gangliosides

Harold C. Miller, William G. Chaney, Norman R. Klinman, Walter J. Esselman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The potential role of gangliosides as modulators of the triggering of neonatal primary B lymphocytes at the single precursor cell level was evaluated. Tolerance was induced in splenic fragment cultures containing an excess of carrier-primed T cells. Gangliosides at low concentrations (20 ng/culture) abrogated the tolerogenic effect of haptens presented on carriers not recognized by environmental T cells. The permanent arrest of immature B-cell responsiveness resulting from tolerogen treatment was eliminated by the presence of gangliosides during tolerogen treatment. The active moiety in the glycolipid preparation which protected B cells during tolerogen treatment was separated by ion-exchange chromatography and demonstrated to be in the disialoganglioside fraction.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalCellular Immunology
Issue number2
StatePublished - Mar 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Regulation of B cell tolerance by murine gangliosides'. Together they form a unique fingerprint.

Cite this