Regulation of E2F: A family of transcription factors involved in proliferation control

Adrian R. Black, Jane Azizkhan-Clifford

Research output: Contribution to journalReview article

101 Scopus citations

Abstract

Members of the E2F family of transcription factors are key participants in orchestration of the cell cycle, cell growth arrest and apoptosis. Therefore, an understanding of the regulation of E2F activity is essential for an understanding of the control of cellular proliferation. E2F activity is regulated by the retinoblastoma family of tumor suppressors and by multiple other mechanisms. This review will describe our current knowledge of these mechanisms which together constitute a highly complex network by which the cell cycle and cellular proliferation can be controlled.

Original languageEnglish (US)
Pages (from-to)281-302
Number of pages22
JournalGene
Volume237
Issue number2
DOIs
StatePublished - Sep 17 1999

Keywords

  • Apoptosis
  • Cell cycle
  • Cell growth
  • Retinoblastoma
  • Transcription

ASJC Scopus subject areas

  • Genetics

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