@article{96010c91d46742abb7ff29973990ccb6,
title = "Regulation of E2F: A family of transcription factors involved in proliferation control",
abstract = "Members of the E2F family of transcription factors are key participants in orchestration of the cell cycle, cell growth arrest and apoptosis. Therefore, an understanding of the regulation of E2F activity is essential for an understanding of the control of cellular proliferation. E2F activity is regulated by the retinoblastoma family of tumor suppressors and by multiple other mechanisms. This review will describe our current knowledge of these mechanisms which together constitute a highly complex network by which the cell cycle and cellular proliferation can be controlled.",
keywords = "Apoptosis, Cell cycle, Cell growth, Retinoblastoma, Transcription",
author = "Black, {Adrian R.} and Jane Azizkhan-Clifford",
note = "Funding Information: The authors would like to acknowledge the other members of the Azizkhan-Clifford laboratory, in particular, Andrew Ippolito who rendered the computer graphics for Fig. 2 . We also gratefully acknowledge those who provided unpublished results and data in press for use in this review. Thanks go to Dr. Jennifer D. Black, without whose support this review would not have been possible, and to baby Helena M. Black, for her company and creative rearranging of reference materials. This work was supported in part by grant RPG-96-147-03-CCG from the American Cancer Society, grant CA71019 from the National Institutes of Health and Institute Core Grant CA16056 from the National Cancer Institute.",
year = "1999",
month = sep,
day = "17",
doi = "10.1016/S0378-1119(99)00305-4",
language = "English (US)",
volume = "237",
pages = "281--302",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "2",
}