Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A

L. Wang, Y. Yang, X. D. Gong, Z. X. Huang, Q. Nie, Z. F. Wang, W. K. Ji, X. H. Hu, W. F. Hu, L. L. Gong, L. Zhang, S. Huang, R. L. Qi, T. H. Yang, Z. G. Chen, W. B. Liu, Y. Z. Liu, D. W C Li

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Original languageEnglish (US)
Pages (from-to)944-951
Number of pages8
JournalCurrent Molecular Medicine
Volume15
Issue number10
DOIs
StatePublished - Dec 1 2015

Keywords

  • Developmental apoptosis
  • Eye development
  • Lens differentiation
  • Serine/threonine phosphatases-1 and -2A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Wang, L., Yang, Y., Gong, X. D., Huang, Z. X., Nie, Q., Wang, Z. F., Ji, W. K., Hu, X. H., Hu, W. F., Gong, L. L., Zhang, L., Huang, S., Qi, R. L., Yang, T. H., Chen, Z. G., Liu, W. B., Liu, Y. Z., & Li, D. W. C. (2015). Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A. Current Molecular Medicine, 15(10), 944-951. https://doi.org/10.2174/156652401510151125125127