Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A

L. Wang; Y. Yang; X. D. Gong; Z. X. Huang; Q. Nie; Z. F. Wang; W. K. Ji; X. H. Hu; W. F. Hu; L. L. Gong; L. Zhang; S. Huang; R. L. Qi; T. H. Yang; Z. G. Chen; W. B. Liu; Y. Z. Liu; D. W C Li

doi:10.2174/156652401510151125125127

Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A

L. Wang, Y. Yang, X. D. Gong, Z. X. Huang, Q. Nie, Z. F. Wang, W. K. Ji, X. H. Hu, W. F. Hu, L. L. Gong, L. Zhang, S. Huang, R. L. Qi, T. H. Yang, Z. G. Chen, W. B. Liu, Y. Z. Liu, D. W C Li

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2 Scopus citations

Abstract

The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Original language	English (US)
Pages (from-to)	944-951
Number of pages	8
Journal	Current Molecular Medicine
Volume	15
Issue number	10
DOIs	https://doi.org/10.2174/156652401510151125125127
State	Published - Dec 1 2015

Keywords

Developmental apoptosis
Eye development
Lens differentiation
Serine/threonine phosphatases-1 and -2A

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology

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10.2174/156652401510151125125127

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Wang, L., Yang, Y., Gong, X. D., Huang, Z. X., Nie, Q., Wang, Z. F., Ji, W. K., Hu, X. H., Hu, W. F., Gong, L. L., Zhang, L., Huang, S., Qi, R. L., Yang, T. H., Chen, Z. G., Liu, W. B., Liu, Y. Z., & Li, D. W. C. (2015). Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A. Current Molecular Medicine, 15(10), 944-951. https://doi.org/10.2174/156652401510151125125127

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title = "Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A",

abstract = "The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.",

keywords = "Developmental apoptosis, Eye development, Lens differentiation, Serine/threonine phosphatases-1 and -2A",

author = "L. Wang and Y. Yang and Gong, {X. D.} and Huang, {Z. X.} and Q. Nie and Wang, {Z. F.} and Ji, {W. K.} and Hu, {X. H.} and Hu, {W. F.} and Gong, {L. L.} and L. Zhang and S. Huang and Qi, {R. L.} and Yang, {T. H.} and Chen, {Z. G.} and Liu, {W. B.} and Liu, {Y. Z.} and Li, {D. W C}",

note = "Publisher Copyright: {\textcopyright} 2015 Bentham Science Publishers.",

year = "2015",

month = dec,

day = "1",

doi = "10.2174/156652401510151125125127",

language = "English (US)",

volume = "15",

pages = "944--951",

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TY - JOUR

T1 - Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A

AU - Wang, L.

AU - Yang, Y.

AU - Gong, X. D.

AU - Huang, Z. X.

AU - Nie, Q.

AU - Wang, Z. F.

AU - Ji, W. K.

AU - Hu, X. H.

AU - Hu, W. F.

AU - Gong, L. L.

AU - Zhang, L.

AU - Huang, S.

AU - Qi, R. L.

AU - Yang, T. H.

AU - Chen, Z. G.

AU - Liu, W. B.

AU - Liu, Y. Z.

AU - Li, D. W C

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

AB - The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

KW - Developmental apoptosis

KW - Eye development

KW - Lens differentiation

KW - Serine/threonine phosphatases-1 and -2A

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SN - 1566-5240

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SP - 944

EP - 951

JO - Current Molecular Medicine

JF - Current Molecular Medicine

IS - 10

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Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A

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Keywords

ASJC Scopus subject areas

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