Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP

Zhong Zhang; Yanle Zhao; Yasir Batres; Ming Fong Lin; Shao Yao Ying

doi:10.1006/bbrc.1997.6649

Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP

Zhong Zhang, Yanle Zhao, Yasir Batres, Ming Fong Lin, Shao Yao Ying

Research output: Contribution to journal › Article › peer-review

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Abstract

Activin A, a homodimer of the βA subunit of inhibin, is a member of the TGF-β family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.

Original language	English (US)
Pages (from-to)	362-365
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	234
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1997.6649
State	Published - May 19 1997

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1997.6649

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title = "Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP",

abstract = "Activin A, a homodimer of the βA subunit of inhibin, is a member of the TGF-β family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.",

author = "Zhong Zhang and Yanle Zhao and Yasir Batres and Lin, {Ming Fong} and Ying, {Shao Yao}",

note = "Funding Information: We thank Dr. Richard L. Wood for his critical review of this manuscript. This work was supported in part by grants from National Institute of Diabetes and Digestive and Kidney Diseases (DK 47609 to S.Y.Y.) and National Cancer Institute (CA 72274 to M.F.L.), respectively.",

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T1 - Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP

AU - Zhang, Zhong

AU - Zhao, Yanle

AU - Batres, Yasir

AU - Lin, Ming Fong

AU - Ying, Shao Yao

N1 - Funding Information: We thank Dr. Richard L. Wood for his critical review of this manuscript. This work was supported in part by grants from National Institute of Diabetes and Digestive and Kidney Diseases (DK 47609 to S.Y.Y.) and National Cancer Institute (CA 72274 to M.F.L.), respectively.

PY - 1997/5/19

Y1 - 1997/5/19

N2 - Activin A, a homodimer of the βA subunit of inhibin, is a member of the TGF-β family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.

AB - Activin A, a homodimer of the βA subunit of inhibin, is a member of the TGF-β family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.

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Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP

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