TY - JOUR
T1 - Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP
AU - Zhang, Zhong
AU - Zhao, Yanle
AU - Batres, Yasir
AU - Lin, Ming Fong
AU - Ying, Shao Yao
PY - 1997/5/19
Y1 - 1997/5/19
N2 - Activin A, a homodimer of the βA subunit of inhibin, is a member of the TGF-β family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.
AB - Activin A, a homodimer of the βA subunit of inhibin, is a member of the TGF-β family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.
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U2 - 10.1006/bbrc.1997.6649
DO - 10.1006/bbrc.1997.6649
M3 - Article
C2 - 9177276
AN - SCOPUS:0031578249
VL - 234
SP - 362
EP - 365
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -