Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP

Zhong Zhang, Yanle Zhao, Yasir Batres, Ming Fong Lin, Shao Yao Ying

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Activin A, a homodimer of the βA subunit of inhibin, is a member of the TGF-β family. It is a multifunctional molecule regulating the growth, differentiation, and survival of a variety of cells. Treatment with activin A to an androgen-sensitive human prostatic cancer cell line LNCaP resulted in growth and morphological change and those were accompanied by up-regulation of prostatic differentiation markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP). In addition, the expression of androgen receptor was also enhanced by activin treatment. These results suggest that activin has significant influence on LNCaP cells.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume234
Issue number2
DOIs
StatePublished - May 19 1997

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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