TY - JOUR
T1 - Regulation of major histocompatibility complex class i molecule expression on cancer cells by amyloid precursor-like protein 2
AU - Peters, Haley L.
AU - Tuli, Amit
AU - Sharma, Mahak
AU - Naslavsky, Naava
AU - Caplan, Steve
AU - MacDonald, Richard G.
AU - Solheim, Joyce C.
N1 - Funding Information:
Acknowledgments We acknowledge the support of an NIH SPORE (P50CA127297) Developmental Research Program Grant and an NIH/NCRR COBRE (P20RR018759) ARRA Nebraska Center for Cellular Signaling Developmental Research Project Grant (to J.C.S. and R.G.M.), NIH Grant GM57428 and a Nebraska Dept. of Health and Human Services Award (to J.C.S.), NIH Grants GM74876 and GM87455 (to S.C.), Nebraska Center for Cellular Signaling Project Leader and Nebraska Dept. of Health and Human Services Awards (to N.N.), UNMC Graduate Studies Fellowships (A.T., and M.S.), a Nebraska Center for Cellular Signaling Fellowship and an American Heart Association Predoctoral Fellowship (to M.S.), an UNMC Graduate Studies Emley and Regents Tuition Fellowships, NIH Training Grant T32 CA009476, and a Graduate Assistance in Areas of National Need Fellowship (to H.P.). We also gratefully acknowledge the assistance of Ms. Jenna Allison and the personnel of the UNMC Cell Analysis Facility and the Monoclonal Antibody Facility. Core facilities at UNMC receive support from NIH Cancer Center Support Grant P30CA036727.
PY - 2011/10
Y1 - 2011/10
N2 - The three members of the amyloid precursor protein family in mammals [amyloid precursor protein, amyloid precursor-like protein 1, and amyloid precursor-like protein 2 (APLP2)] have been implicated in a large array of intracellular processes, which include development, transcription, apoptosis, metabolism, and the cell cycle. A series of studies by our laboratories has demonstrated that APLP2 is highly expressed by many cancer cell lines (with the highest expression in pancreatic cancer cell lines) and that it facilitates major histocompatibility complex (MHC) class I molecule endocytosis. This review focuses on this recently revealed function of APLP2 relevant to tumor immunology: that it acts as a novel regulator of MHC class I molecule surface expression.
AB - The three members of the amyloid precursor protein family in mammals [amyloid precursor protein, amyloid precursor-like protein 1, and amyloid precursor-like protein 2 (APLP2)] have been implicated in a large array of intracellular processes, which include development, transcription, apoptosis, metabolism, and the cell cycle. A series of studies by our laboratories has demonstrated that APLP2 is highly expressed by many cancer cell lines (with the highest expression in pancreatic cancer cell lines) and that it facilitates major histocompatibility complex (MHC) class I molecule endocytosis. This review focuses on this recently revealed function of APLP2 relevant to tumor immunology: that it acts as a novel regulator of MHC class I molecule surface expression.
KW - Amyloid precursor-like protein 2
KW - Antigen presentation
KW - Cancer
KW - Endocytosis
KW - Human leukocyte antigen
KW - Major histocompatibility complex class I molecule
KW - Trafficking
KW - Tumor antigen
KW - Tumor immunology
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U2 - 10.1007/s12026-011-8238-6
DO - 10.1007/s12026-011-8238-6
M3 - Article
C2 - 21826533
AN - SCOPUS:80053563841
SN - 0257-277X
VL - 51
SP - 39
EP - 44
JO - Immunologic Research
JF - Immunologic Research
IS - 1
ER -