Regulation of melanoma by the embryonic skin

M. Gerschenson, K. Graves, S. D. Carson, R. S. Wells, G. B. Pierce

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

This report focuses on the regulation of murine melanoma by the embryonic skin. A surgical technique was developed to allow injection of B16 melanoma cells into the embryo in utero. A significant decrease in incidence of tumors was noted, which correlated with the time of arrival of normally migrating premelanocytes into the skin. Media were conditioned from skin explanted at the time premelanocytes arrive in it; these media inhibited the growth of melanoma cells in vitro. Under optimal conditions the growth of melanoma cells ceased; the cells had altered morphology and failed to proliferate when placed in fresh growth media.

Original languageEnglish (US)
Pages (from-to)7307-7310
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number19
DOIs
StatePublished - Dec 19 1986

ASJC Scopus subject areas

  • General

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