TY - JOUR
T1 - Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases
AU - Hynes-Smith, R. Willow
AU - Wittorf, Karli J.
AU - Buckley, Shannon M.
N1 - Funding Information:
S.M.B. is supported by the National Institutes of Health ( P20GM121316 ) COBRE award. W.H.S. is supported by the UNMC NIH training grant ( 5T32CA009476-23 ). This publication was supported by the Fred & Pamela Buffett Cancer Center Support Grant from the National Cancer Institute under award number P30 CA036727 .
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/12
Y1 - 2020/12
N2 - Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.
AB - Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.
KW - FBOX proteins
KW - hematopoiesis
KW - ubiquitin E3 ligases
KW - ubiquitin proteasome system
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U2 - 10.1016/j.it.2020.10.003
DO - 10.1016/j.it.2020.10.003
M3 - Review article
C2 - 33160841
AN - SCOPUS:85095763744
VL - 41
SP - 1128
EP - 1140
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 12
ER -