Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases

R. Willow Hynes-Smith, Karli J. Wittorf, Shannon M. Buckley

Research output: Contribution to journalReview articlepeer-review

Abstract

Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.

Original languageEnglish (US)
Pages (from-to)1128-1140
Number of pages13
JournalTrends in Immunology
Volume41
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • FBOX proteins
  • hematopoiesis
  • ubiquitin E3 ligases
  • ubiquitin proteasome system

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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