Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases

R. Willow Hynes-Smith; Karli J. Wittorf; Shannon M. Buckley

doi:10.1016/j.it.2020.10.003

Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases

R. Willow Hynes-Smith, Karli J. Wittorf, Shannon M. Buckley

Research output: Contribution to journal › Review article › peer-review

Abstract

Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.

Original language	English (US)
Pages (from-to)	1128-1140
Number of pages	13
Journal	Trends in Immunology
Volume	41
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2020.10.003
State	Published - Dec 2020

Keywords

FBOX proteins
hematopoiesis
ubiquitin E3 ligases
ubiquitin proteasome system

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.it.2020.10.003

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title = "Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases",

abstract = "Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.",

keywords = "FBOX proteins, hematopoiesis, ubiquitin E3 ligases, ubiquitin proteasome system",

author = "Hynes-Smith, {R. Willow} and Wittorf, {Karli J.} and Buckley, {Shannon M.}",

note = "Funding Information: S.M.B. is supported by the National Institutes of Health ( P20GM121316 ) COBRE award. W.H.S. is supported by the UNMC NIH training grant ( 5T32CA009476-23 ). This publication was supported by the Fred & Pamela Buffett Cancer Center Support Grant from the National Cancer Institute under award number P30 CA036727 .",

year = "2020",

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doi = "10.1016/j.it.2020.10.003",

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AU - Hynes-Smith, R. Willow

AU - Wittorf, Karli J.

AU - Buckley, Shannon M.

N1 - Funding Information: S.M.B. is supported by the National Institutes of Health ( P20GM121316 ) COBRE award. W.H.S. is supported by the UNMC NIH training grant ( 5T32CA009476-23 ). This publication was supported by the Fred & Pamela Buffett Cancer Center Support Grant from the National Cancer Institute under award number P30 CA036727 .

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N2 - Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.

AB - Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is maintained throughout life by hematopoietic stem cells and requires a controlled balance between self-renewal, differentiation, and quiescence. Disrupting this balance can result in hematopoietic malignancies, including anemia, immune deficiency, leukemia, and lymphoma. Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance. In this review, we detail how FBOX proteins target specific proteins for degradation to regulate hematopoiesis through cell processes, such as cell cycle, development, and apoptosis.

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KW - ubiquitin proteasome system

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