Abstract
Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.
| Original language | English (US) |
|---|---|
| Article number | e34921 |
| Journal | PloS one |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2012 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
- General
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Wang, Y., Solt, L. A., Kojetin, D. J., & Burris, T. P. (2012). Regulation of p53 stability and apoptosis by a ROR agonist. PloS one, 7(4), [e34921]. https://doi.org/10.1371/journal.pone.0034921