Regulation of p53 stability and apoptosis by a ROR agonist

Yongjun Wang; Laura A. Solt; Douglas J. Kojetin; Thomas P. Burris

doi:10.1371/journal.pone.0034921

Regulation of p53 stability and apoptosis by a ROR agonist

Yongjun Wang, Laura A. Solt, Douglas J. Kojetin, Thomas P. Burris

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

Original language	English (US)
Article number	e34921
Journal	PloS one
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0034921
State	Published - 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

Access to Document

10.1371/journal.pone.0034921

Fingerprint Dive into the research topics of 'Regulation of p53 stability and apoptosis by a ROR agonist'. Together they form a unique fingerprint.

Cite this

@article{a20269010d5749eda1e4599e1c7b86eb,

title = "Regulation of p53 stability and apoptosis by a ROR agonist",

abstract = "Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.",

author = "Yongjun Wang and Solt, {Laura A.} and Kojetin, {Douglas J.} and Burris, {Thomas P.}",

year = "2012",

doi = "10.1371/journal.pone.0034921",

language = "English (US)",

volume = "7",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "4",

}

TY - JOUR

T1 - Regulation of p53 stability and apoptosis by a ROR agonist

AU - Wang, Yongjun

AU - Solt, Laura A.

AU - Kojetin, Douglas J.

AU - Burris, Thomas P.

PY - 2012

Y1 - 2012

N2 - Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

AB - Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

UR - http://www.scopus.com/inward/record.url?scp=84859626370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859626370&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0034921

DO - 10.1371/journal.pone.0034921

M3 - Article

C2 - 22509368

AN - SCOPUS:84859626370

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e34921

ER -

Regulation of p53 stability and apoptosis by a ROR agonist

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this