Regulation of p53 stability and apoptosis by a ROR agonist

Yongjun Wang; Laura A. Solt; Douglas J. Kojetin; Thomas P. Burris

doi:10.1371/journal.pone.0034921

Regulation of p53 stability and apoptosis by a ROR agonist

Yongjun Wang, Laura A. Solt, Douglas J. Kojetin, Thomas P. Burris

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

Original language	English (US)
Article number	e34921
Journal	PloS one
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0034921
State	Published - 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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10.1371/journal.pone.0034921

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AU - Burris, Thomas P.

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AB - Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

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Regulation of p53 stability and apoptosis by a ROR agonist

Abstract

ASJC Scopus subject areas

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