Regulative characteristics of β-adrenoreceptor subtypal function in patients with essential hypertension by chronic β1-selective antagonist

P. Yingxin, M. Shuping, L. Yulong

Research output: Contribution to journalArticle

Abstract

Objective To study the effect of chronic β1-selective blockor treatment on β-adrenoreceptor subtypal function in human. Methods Cardiac β1-adrenoreceptor subtypes responsiveness were measured by treadmill exercise test and cardiac β2-adrenoreceptor responsiveness by salbutamol injection test in 20 male patients with essential hypertension (EH) after β1-selective blockor treatment for at least 4 months and withdrawal for 3 days. The twenty male patients with EH and non-β-blockors treatment for at least 4 months were used as controls. Results The increases in peak exercise heart rate by treadmill were not significantly different between the patients with β1-blockor treatment and those with non-β-blockor treatment. The chronotropic dose of salbutamol that increased heart rate by 30 beats/min [chronotropic dose 30 (CD30)] in [β1-blockor treatment group were significantly lower than those in non-β-blockor treatment group (1.8 ± 0.3 vs 2.7 ± 0.2 μg/kg, P < 0.001). Blood pressures did not change significantly after salbutamol injection in both groups. Conclusion The treatment with β1-selective blockor leads to cross sensitisation of cardiac β2-adrenoreceptor in human. This is the possible celluological mechanism of the β-blockor withdrawal syndrome.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
JournalChinese Journal of Cardiology
Volume26
Issue number5
StatePublished - Dec 1 1998

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Keywords

  • Adrenergic
  • Adrenergic beta-antagonists
  • Beta-1
  • Hypertension receptors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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