Regulatory effects of adrenal gland products in IgG immune complex acute lung injury

Larry D. Crouch, Alex B. Lentsch, Roscoe L. Warner, Kent J. Johnson, Peter A. Ward

Research output: Contribution to journalArticle

Abstract

Adrenal gland-derived corticosterone and epinephrine are thought to function as endogenous antiinflammatory mediators of inflammatory injury. To determine whether adrenalectomy impacts inflammatory processes associated with IgG immune complex-mediated acute lung injury, adrenalectomized and sham adrenal-ectomized Long Evans rats were treated with IgG or saline intratracheally. IgG immune complex lung injury resulted in a two-fold increase in pulmonary vascular permeability for serum albumin in adrenalectomized rats, compared to adrenal-intact animals. This increase in injury was associated with increases in NF-κB activity in whole lung homogenates, bronchoalveolar lavage fluid TNFα concentrations, pulmonary vascular ICAM-1 expression and whole lung myeloperoxidase activity. Adrenalectomy did not alter nitric oxide content in bronchoalveolar lavage fluid. Adrenalectomized saline-treated rats also had increased ICAM-1 expression and pulmonary vascular permeability, compared to saline-treated adrenal-intact sham animals. These data suggest that adrenal gland-derived mediators regulate either directly or indirectly several parameters of inflammatory signaling and activation in the IgG immune complex-injured lung.

Original languageEnglish (US)
Pages (from-to)A124
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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    Crouch, L. D., Lentsch, A. B., Warner, R. L., Johnson, K. J., & Ward, P. A. (1997). Regulatory effects of adrenal gland products in IgG immune complex acute lung injury. FASEB Journal, 11(3), A124.