Abstract
The role of interleukin-11 (IL-11) was evaluated in the IgG immune complex model of acute lung injury in rats. IL-11 mRNA and protein were both up-regulated during the course of this inflammatory response. Exogenously administered IL-11 substantially reduced, in a dose-dependent manner, the intrapulmonary accumulation of neutrophils and the lung vascular leak of albumin. These in vivo anti-inflammatory effects of IL-11 were associated with reduced NF-κB activation in lung, reduced levels of tumor necrosis factor α (TNF-α) in bronchoalveolar lavage (BAL) fluids, and diminished up- regulation of lung vascular ICAM-1. It is interesting that IL-11 did not affect BAL fluid content of the CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-inducible neutrophil chemoattractant (CINC); the presence of IL-11 did not affect these chemokines. However, BAL content of C5a was reduced by IL-11. These data indicate that IL-11 is a regulatory cytokine in the lung and that, like other members of this family, its anti- inflammatory properties appear to be linked to its suppression of NF-κB activation, diminished production of TNF-α, and reduced up-regulation of lung vascular ICAM-1.
Original language | English (US) |
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Pages (from-to) | 151-157 |
Number of pages | 7 |
Journal | Journal of Leukocyte Biology |
Volume | 66 |
Issue number | 1 |
DOIs | |
State | Published - 1999 |
Keywords
- C5α
- Chemokines
- ICAM-1
- NF-κB
- Neutrophils
- Tumor necrosis factor α
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Cell Biology