Regulatory evolution across the protein interaction network

Bernardo Lemos; Colin D. Meiklejohn; Daniel L. Hartl

doi:10.1038/ng1427

Regulatory evolution across the protein interaction network

Bernardo Lemos, Colin D. Meiklejohn, Daniel L. Hartl

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Protein-protein interactions may impose constraints on both structural and regulatory evolution. Here we show that protein-protein interactions are negatively associated with evolutionary variation in gene expression. Moreover, interacting proteins have similar levels of variation in expression, and their expression levels are positively correlated across strains. Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionary coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies.

Original language	English (US)
Pages (from-to)	1059-1060
Number of pages	2
Journal	Nature Genetics
Volume	36
Issue number	10
DOIs	https://doi.org/10.1038/ng1427
State	Published - Oct 2004
Externally published	Yes

ASJC Scopus subject areas

Genetics

Access to Document

10.1038/ng1427

Fingerprint Dive into the research topics of 'Regulatory evolution across the protein interaction network'. Together they form a unique fingerprint.

Cite this

@article{15f71cb025584756b6b25128e2d0f7b1,

title = "Regulatory evolution across the protein interaction network",

abstract = "Protein-protein interactions may impose constraints on both structural and regulatory evolution. Here we show that protein-protein interactions are negatively associated with evolutionary variation in gene expression. Moreover, interacting proteins have similar levels of variation in expression, and their expression levels are positively correlated across strains. Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionary coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies.",

author = "Bernardo Lemos and Meiklejohn, {Colin D.} and Hartl, {Daniel L.}",

note = "Funding Information: We thank D. Hewitt, R. Frankham, J. Blumenstiel, J. Parsch and members of the laboratory of D.L.H. for suggestions. This work was supported by grants from the US National Institutes of Health to D.L.H.",

year = "2004",

month = oct,

doi = "10.1038/ng1427",

language = "English (US)",

volume = "36",

pages = "1059--1060",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

TY - JOUR

T1 - Regulatory evolution across the protein interaction network

AU - Lemos, Bernardo

AU - Meiklejohn, Colin D.

AU - Hartl, Daniel L.

N1 - Funding Information: We thank D. Hewitt, R. Frankham, J. Blumenstiel, J. Parsch and members of the laboratory of D.L.H. for suggestions. This work was supported by grants from the US National Institutes of Health to D.L.H.

PY - 2004/10

Y1 - 2004/10

N2 - Protein-protein interactions may impose constraints on both structural and regulatory evolution. Here we show that protein-protein interactions are negatively associated with evolutionary variation in gene expression. Moreover, interacting proteins have similar levels of variation in expression, and their expression levels are positively correlated across strains. Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionary coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies.

AB - Protein-protein interactions may impose constraints on both structural and regulatory evolution. Here we show that protein-protein interactions are negatively associated with evolutionary variation in gene expression. Moreover, interacting proteins have similar levels of variation in expression, and their expression levels are positively correlated across strains. Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionary coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies.

UR - http://www.scopus.com/inward/record.url?scp=6944224155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6944224155&partnerID=8YFLogxK

U2 - 10.1038/ng1427

DO - 10.1038/ng1427

M3 - Article

C2 - 15378060

AN - SCOPUS:6944224155

VL - 36

SP - 1059

EP - 1060

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 10

ER -

Regulatory evolution across the protein interaction network

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this