Relationship between rosai-dorfman disease and IgG4-related disease: Study of 32 cases

Liping Liu, Anamarija M. Perry, Wenfeng Cao, Lynette M. Smith, Eric D. Hsi, Xiuli Liu, Jun Q. Mo, Snjezana Dotlic, Marina Mosunjac, Geoffrey Talmon, Dennis D. Weisenburger, Kai Fu

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Objectives: To assess the association between Rosai- Dorfman disease (RDD) and IgG4-related disease (IgG4-RD). Methods: We studied the number of IgG4-positive plasma cells and the IgG4/IgG ratio in 32 biopsy specimens (13 nodal, 19 extranodal) from 29 patients with RDD and compared the findings with those in IgG4-RD of the pancreas and reactive lymph nodes. We also assessed the number of FOXP3-positive regulatory T cells (Tregs) since they were reported to be increased in IgG4-RD. Results: We found that RDD cases had much lower numbers of IgG4-positive plasma cells and lower IgG4/IgG ratios compared with IgG4-RD but were similar to reactive lymph nodes. Furthermore, RDD had lower numbers of FOXP3- positive Tregs than did IgG4-RD. There were no significant differences in the number of IgG4-positive plasma cells and the IgG4/IgG ratio between the nodal and extranodal RDD cases. Conclusions: Our study suggests that RDD does not belong in the spectrum of IgG4-RD.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalAmerican journal of clinical pathology
Volume140
Issue number3
DOIs
StatePublished - Sep 2013

Keywords

  • IgG4-related disease
  • IgG4/IgG ratio
  • Regulatory T cells
  • Rosai-Dorfman disease
  • Sinus histiocytosis with massive lymphadenopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Liu, L., Perry, A. M., Cao, W., Smith, L. M., Hsi, E. D., Liu, X., Mo, J. Q., Dotlic, S., Mosunjac, M., Talmon, G., Weisenburger, D. D., & Fu, K. (2013). Relationship between rosai-dorfman disease and IgG4-related disease: Study of 32 cases. American journal of clinical pathology, 140(3), 395-402. https://doi.org/10.1309/AJCPFH0SJ6YILXJU