Relationship of selenium to high energy phosphate compounds in muscle of dystrophic mice

A. J. Barak, T. B. Allison, M. F. Sorrell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

It has been suggested that selenium may possibly be related to creatine metabolism in muscle. In this study selenium containing and selenium deficient diets were fed to dystrophic mice. The effect of this feeding on the levels of high energy phosphate compounds involved in creatine metabolism in muscle tissue was measured. It was observed that the levels of ATP and creatine phosphate in dystrophic muscle were significantly lower than levels in control tissue and the feeding of the diets were ineffectual in altering these levels. The low levels of glucose 6 phosphate also observed in dystrophic muscle suggest that in this tissue a lesion may exist in glycolysis which may effect other metabolic pathways including that for creatine. (14 references).

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalNutrition Reports International
Volume10
Issue number5
StatePublished - 1974

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Biochemistry
  • Endocrinology

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