TY - JOUR
T1 - Relationships between neurologic disorders and hereditary hearing loss
AU - Smith, Shelley D.
N1 - Funding Information:
From the Department of Pediatrics, Center for Human Molecular Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE. This study was funded m part by NIH-NIDCD RO1-DC02942. Address reprint requests to Shelley D. Smith, PhD, Department of Pediatrics, Center for Human Molecular Genetics, Munroe Meyer Institute, Universi~' of Nebraska Medical Center, 985455 Nebraska Medical Center, Omaha, NE 68198-5455. Copyright 9 2001 by W.B. Saunders Company 1071-9091/01/0803-0004535.00/0 doi: l O.1 053/sperL 2001.26448
PY - 2001
Y1 - 2001
N2 - Hearing loss is a common disorder that often has a neurologic etiology. Recently, there has been significant progress in the discovery of the genes that cause sensorineural hearing loss, and this has led to increased understanding of the pathophysiology of both syndromic and nonsyndromic hearing problems. These genes cover the range of processes involved in neurologic development and function, including structural genes, transcription factors, and tumor suppressors; genes involved in signal transduction processes, such as ion homeostasis and intracellular transport; and mitochondrial genes responsible for oxidative phosphorylation and energy production. Interactions between genes as well as between genes and environmental factors have also been documented. Understanding of these processes should lead to earlier and more accurate diagnosis and more effective treatment for neurologic disorders and hearing loss.
AB - Hearing loss is a common disorder that often has a neurologic etiology. Recently, there has been significant progress in the discovery of the genes that cause sensorineural hearing loss, and this has led to increased understanding of the pathophysiology of both syndromic and nonsyndromic hearing problems. These genes cover the range of processes involved in neurologic development and function, including structural genes, transcription factors, and tumor suppressors; genes involved in signal transduction processes, such as ion homeostasis and intracellular transport; and mitochondrial genes responsible for oxidative phosphorylation and energy production. Interactions between genes as well as between genes and environmental factors have also been documented. Understanding of these processes should lead to earlier and more accurate diagnosis and more effective treatment for neurologic disorders and hearing loss.
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U2 - 10.1053/spen.2001.26448
DO - 10.1053/spen.2001.26448
M3 - Article
C2 - 11575844
AN - SCOPUS:0034824284
SN - 1071-9091
VL - 8
SP - 147
EP - 159
JO - Seminars in Pediatric Neurology
JF - Seminars in Pediatric Neurology
IS - 3
ER -