Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular Lymphoma

Michael R. Green, Maher K. Gandhi, Mark J. Courtney, Paula Marlton, Lyn Griffiths

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFκB-responsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NFκB activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFκB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFκB activity in FL, and could potentially be used as a marker for this gene signature.

Original languageEnglish (US)
Pages (from-to)1699-1702
Number of pages4
JournalLeukemia Research
Volume33
Issue number12
DOIs
StatePublished - Dec 2009
Externally publishedYes

Keywords

  • FOXP1
  • Follicular Lymphoma
  • NFκB
  • Non-Hodgkin's Lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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