TY - JOUR
T1 - Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India
T2 - A review of 971 cases
AU - Perry, Anamarija M.
AU - Diebold, Jacques
AU - Nathwani, Bharat N.
AU - Maclennan, Kenneth A.
AU - Müller-Hermelink, Hans K.
AU - Bast, Martin
AU - Boilesen, Eugene
AU - Armitage, James O.
AU - Weisenburger, Dennis D.
N1 - Publisher Copyright:
© 2016 John Wiley & Sons Ltd.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.
AB - Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.
KW - Epidemiology
KW - Middle East
KW - Non-Hodgkin lymphoma
KW - North Africa
UR - http://www.scopus.com/inward/record.url?scp=84958936700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958936700&partnerID=8YFLogxK
U2 - 10.1111/bjh.13876
DO - 10.1111/bjh.13876
M3 - Article
C2 - 26684877
AN - SCOPUS:84958936700
SN - 0007-1048
VL - 172
SP - 699
EP - 708
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 5
ER -