Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis

Robert G. Bennett, Dean G. Heimann, Dean J. Tuma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

The effect of relaxin administration before (prevention) or after (treatment) the establishment of hepatic fibrosis in a mouse model was examined. In the prevention study, relaxin reduced collagen and smooth muscle actin content and significantly reduced serum levels of the liver enzymes alanine aminotransferase and aspartate aminotransferase. In the treatment study, administration of relaxin for 1 week reduced collagen and smooth muscle actin but not liver enzyme levels. Relaxin administered for 2 weeks had no significant effect. In conclusion, the data suggest that relaxin treatment before fibrosis can reduce collagen and improve liver function but that there is little effect of short-term relaxin treatment after fibrosis is established.

Original languageEnglish (US)
Title of host publicationRelaxin and Related Peptides Fifth International Conference
PublisherBlackwell Publishing Inc.
Pages348-349
Number of pages2
ISBN (Print)9781573317214
DOIs
StatePublished - Apr 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1160
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Collagen
  • Hepatic fibrosis
  • Liver
  • Relaxin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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