Release by ethanol of vitamins into rat liver perfusates

M. F. Sorrell, H. Baker, A. J. Barak, O. Frank

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In vitro perfusion of rat liver with ethanol (EtOH) causes a release of all vitamins from the liver stores, except biotin, vitamins A, E, C, and β carotene. The concentration of vitamins released from the liver by EtOH in decreasing order was B12 > B6 > pantothenate > thiamin > riboflavin > nicotinate > folate. The B12 concentration in the EtOH perfusate was high when compared with the perfusate without EtOH, implying that B12 can be rapidly released from a liver exposed to EtOH. Results also suggest that when a liver exposed to EtOH releases a vitamin from its stores, it cannot rebind the released vitamin while EtOH is being recirculated.

Original languageEnglish (US)
Pages (from-to)743-745
Number of pages3
JournalAmerican Journal of Clinical Nutrition
Volume27
Issue number7
DOIs
StatePublished - 1974

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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