TY - JOUR
T1 - Relevance of molecular mimicry in the mediation of infectious myocarditis
AU - Massilamany, Chandirasegaran
AU - Huber, Sally A.
AU - Cunningham, Madeleine W.
AU - Reddy, Jay
N1 - Funding Information:
Acknowledgments This work was supported by the American Heart Association and the Children’s Cardiomyopathy Foundation (SDG2462390204001, JR), and the National Institutes of Health (HL114669, JR; HL108371, SAH; HL56267, MWC). CM is a recipient of a postdoctoral research fellowship grant awarded by the Myocarditis Foundation, NJ.
PY - 2014/3
Y1 - 2014/3
N2 - Heart disease, the leading cause of death in humans, is estimated to affect one in four American adults in some form. One predominant cause of heart failure in young adults is myocarditis, which can lead to the development of dilated cardiomyopathy, a major indication for heart transplantation. Environmental microbes, including viruses, bacteria, and fungi that are otherwise innocuous, have the potential to induce inflammatory heart disease. As the list is growing, it is critical to determine the mechanisms by which microbes can trigger heart autoimmunity and, importantly, to identify their target antigens. This is especially true as microbes showing structural similarities with the cardiac antigens can predispose to heart autoimmunity by generating cross-reactive immune responses. In this review, we discuss the relevance of molecular mimicry in the mediation of infectious myocarditis.
AB - Heart disease, the leading cause of death in humans, is estimated to affect one in four American adults in some form. One predominant cause of heart failure in young adults is myocarditis, which can lead to the development of dilated cardiomyopathy, a major indication for heart transplantation. Environmental microbes, including viruses, bacteria, and fungi that are otherwise innocuous, have the potential to induce inflammatory heart disease. As the list is growing, it is critical to determine the mechanisms by which microbes can trigger heart autoimmunity and, importantly, to identify their target antigens. This is especially true as microbes showing structural similarities with the cardiac antigens can predispose to heart autoimmunity by generating cross-reactive immune responses. In this review, we discuss the relevance of molecular mimicry in the mediation of infectious myocarditis.
KW - Autoimmunity
KW - Coxsackievirus
KW - Heart, infectious myocarditis
KW - Microbial mimics
KW - Mimicry epitopes
KW - Molecular mimicry
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U2 - 10.1007/s12265-013-9519-3
DO - 10.1007/s12265-013-9519-3
M3 - Article
C2 - 24263348
AN - SCOPUS:84896358752
VL - 7
SP - 165
EP - 171
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
SN - 1937-5387
IS - 2
ER -