Relevance of molecular mimicry in the mediation of infectious myocarditis

Chandirasegaran Massilamany, Sally A. Huber, Madeleine W. Cunningham, Jay Reddy

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Heart disease, the leading cause of death in humans, is estimated to affect one in four American adults in some form. One predominant cause of heart failure in young adults is myocarditis, which can lead to the development of dilated cardiomyopathy, a major indication for heart transplantation. Environmental microbes, including viruses, bacteria, and fungi that are otherwise innocuous, have the potential to induce inflammatory heart disease. As the list is growing, it is critical to determine the mechanisms by which microbes can trigger heart autoimmunity and, importantly, to identify their target antigens. This is especially true as microbes showing structural similarities with the cardiac antigens can predispose to heart autoimmunity by generating cross-reactive immune responses. In this review, we discuss the relevance of molecular mimicry in the mediation of infectious myocarditis.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalJournal of Cardiovascular Translational Research
Volume7
Issue number2
DOIs
StatePublished - Mar 2014

Keywords

  • Autoimmunity
  • Coxsackievirus
  • Heart, infectious myocarditis
  • Microbial mimics
  • Mimicry epitopes
  • Molecular mimicry

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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