Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration

Yasir J. Sepah; Mohammad A. Sadiq; Aymen Rashid; Roomasa Channa; Elham Hatef; Diana V. Do; Quan Dong Nguyen

doi:10.12688/f1000research.2-131.v2

Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration

Yasir J. Sepah, Mohammad A. Sadiq, Aymen Rashid, Roomasa Channa, Elham Hatef, Diana V. Do, Quan Dong Nguyen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus TM OCT, and the Spectral Domain (SD-OCT) Spectralis TM and Cirrus TM OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration. Design: Prospective observational study. Methods: Setting: University-based retina practice. Patients: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD. Procedure: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices. Main Outcome Measures: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability. Results: Spectralis had the highest number of images needing manual correction. All machines had high ICCs, with Spectralis having the highest. Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™. The CORs were lowest for Spectralis TM and similar and higher for Cirrus TM and Stratus TM. Agreement, CORs, and ICCs generally improved after manual correction, but only minimally. Conclusion: Agreement is low between devices, except between both SD-OCT machines. Manual correction tends to improve results.

Original language	English (US)
Journal	F1000Research
Volume	2
DOIs	https://doi.org/10.12688/f1000research.2-131.v2
State	Published - Mar 5 2015

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.12688/f1000research.2-131.v2

Cite this

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title = "Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration",

abstract = "Purpose: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus TM OCT, and the Spectral Domain (SD-OCT) Spectralis TM and Cirrus TM OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration. Design: Prospective observational study. Methods: Setting: University-based retina practice. Patients: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD. Procedure: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices. Main Outcome Measures: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability. Results: Spectralis had the highest number of images needing manual correction. All machines had high ICCs, with Spectralis having the highest. Also, Bland-Altman plots indicated that there was low agreement between Cirrus{\texttrademark} and Stratus{\texttrademark}, Spectralis{\texttrademark} and Stratus{\texttrademark}, while there was good agreement between the Cirrus{\texttrademark} and Spectralis{\texttrademark}. The CORs were lowest for Spectralis TM and similar and higher for Cirrus TM and Stratus TM. Agreement, CORs, and ICCs generally improved after manual correction, but only minimally. Conclusion: Agreement is low between devices, except between both SD-OCT machines. Manual correction tends to improve results.",

author = "Sepah, {Yasir J.} and Sadiq, {Mohammad A.} and Aymen Rashid and Roomasa Channa and Elham Hatef and Do, {Diana V.} and Nguyen, {Quan Dong}",

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year = "2015",

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T1 - Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration

AU - Sepah, Yasir J.

AU - Sadiq, Mohammad A.

AU - Rashid, Aymen

AU - Channa, Roomasa

AU - Hatef, Elham

AU - Do, Diana V.

AU - Nguyen, Quan Dong

PY - 2015/3/5

Y1 - 2015/3/5

N2 - Purpose: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus TM OCT, and the Spectral Domain (SD-OCT) Spectralis TM and Cirrus TM OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration. Design: Prospective observational study. Methods: Setting: University-based retina practice. Patients: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD. Procedure: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices. Main Outcome Measures: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability. Results: Spectralis had the highest number of images needing manual correction. All machines had high ICCs, with Spectralis having the highest. Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™. The CORs were lowest for Spectralis TM and similar and higher for Cirrus TM and Stratus TM. Agreement, CORs, and ICCs generally improved after manual correction, but only minimally. Conclusion: Agreement is low between devices, except between both SD-OCT machines. Manual correction tends to improve results.

AB - Purpose: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus TM OCT, and the Spectral Domain (SD-OCT) Spectralis TM and Cirrus TM OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration. Design: Prospective observational study. Methods: Setting: University-based retina practice. Patients: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD. Procedure: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices. Main Outcome Measures: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability. Results: Spectralis had the highest number of images needing manual correction. All machines had high ICCs, with Spectralis having the highest. Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™. The CORs were lowest for Spectralis TM and similar and higher for Cirrus TM and Stratus TM. Agreement, CORs, and ICCs generally improved after manual correction, but only minimally. Conclusion: Agreement is low between devices, except between both SD-OCT machines. Manual correction tends to improve results.

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Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration

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