Remodeling and elasticity changes in human vein grafts

J. G. Jacot, I. Abdullah, M. Belkin, M. C. Donaldson, A. D. Whittemore, M. S. Conte

Research output: Contribution to journalConference articlepeer-review

Abstract

Duplex ultrasound measurements of patients (N=65) undergoing lower extremity bypass with autologous veins were taken at surgery and multiple times after surgery. Changes in lumen diameter were correlated with changes in external graft diameter (p<0.001) but not with wall area. Changes in lumen diameter were also negatively correlated with initial lumen diameter (p<0.05). Grafts showed a marked increase in wall elastic modulus between 1 and 3 months postoperatively. In this same time, graft wall tension decreased to a level not significantly different to that in the normal superficial femoral artery (SFA). These results suggest complex remodeling of vein grafts with wall growth that alleviates wall tension, independent from changes in lumenal diameter.

Original languageEnglish (US)
Pages (from-to)1325-1326
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Elasticity
  • Vascular remodeling
  • Vein grafts

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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