This paper introduces an on-going research effort for integrating a wireless monitoring system to evaluate the long-term structural behavior of honeycomb fiber reinforced polymer (FRP) sandwich panels for bridge deck systems. The effort includes developing analytical models for evaluating the structural behavior of the panels and experimentally investigating the practicality and reliability of using wireless sensor systems for health monitoring. In the analytical part, three finite element models and one simplified I-beam model are to predict the structural behaviors of FRP sandwich panels. In the experimental part, a wireless sensor system is applied to measure structural response of FRP panels under static loading. The results of the analytical and experimental models are compared to evaluate the applicability of the wireless sensor system and validate the results of the analytical models. Conclusions are drawn from two aspects: first, preferable modeling methods are recommended in conducting structural analysis; second, the reliability and accuracy of the wireless sensor system is assessed.