Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia

Sarah A. Holstein, John B. Stokes, Raymond J. Hohl

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Tyrosine kinase inhibitors (TKIs) directed against the Bcr-Abl kinase have revolutionized the treatment of chronic myelogenous leukemia (CML). Relatively little is known regarding the effects of these agents on the kidney. Clinically, there have been a handful of reports associating imatinib with acute renal failure. Preclinical reports indicate that imatinib inhibits signaling pathways which may play a role in renal injury. We report the case of a patient with imatinib-resistant CML who developed renal failure after being placed on dasatinib. When she later became resistant to dasatinib she was switched to nilotinib. Shortly thereafter, she became dialysis-independent. Second-generation Bcr-Abl TKIs may influence renal function based on differential inhibition of related tyrosine kinases.

Original languageEnglish (US)
Pages (from-to)344-347
Number of pages4
JournalLeukemia Research
Volume33
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

Keywords

  • Bcr-Abl tyrosine kinase inhibitor
  • Chronic myelogenous leukemia
  • Renal failure

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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