Renal sympathetic nerve-derived signaling in acute and chronic kidney diseases

Mi Ra Noh, Hee Seong Jang, Jinu Kim, Babu J. Padanilam

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The kidney is innervated by afferent sensory and efferent sympathetic nerve fibers. Norepinephrine (NE) is the primary neurotransmitter for post-ganglionic sympathetic adrenergic nerves, and its signaling, regulated through adrenergic receptors (AR), modulates renal function and pathophysiology under disease conditions. Renal sympathetic overactivity and increased NE level are commonly seen in chronic kidney disease (CKD) and are critical factors in the progression of renal disease. Blockade of sympathetic nerve-derived signaling by renal denervation or AR blockade in clinical and experimental studies demonstrates that renal nerves and its downstream signaling contribute to progression of acute kidney injury (AKI) to CKD and fibrogenesis. This review summarizes our current knowledge of the role of renal sympathetic nerve and adrenergic receptors in AKI, AKI to CKD transition and CKDand provides new insights into the therapeutic potential of intervening in its signaling pathways.

Original languageEnglish (US)
Article number1647
JournalInternational journal of molecular sciences
Issue number5
StatePublished - Mar 2020


  • Acute kidney injury
  • Adrenergic receptor
  • Chronic kidney disease
  • Norepinephrine
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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