Reperfused vs. nonreperfused myocardial infarction: When to use which model

Merry L. Lindsey, Lisandra E. de Castro Brás, Kristine Y. DeLeon-Pennell, Nikolaos G. Frangogiannis, Ganesh V. Halade, Caitlin C. O'Meara, Francis G. Spinale, Zamaneh Kassiri, Jonathan A. Kirk, Petra Kleinbongard, Crystal M. Ripplinger, Keith R. Brunt

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.

Original languageEnglish (US)
Pages (from-to)H208-H213
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number1
StatePublished - Jul 2021


  • Cardiac
  • Cardiomyocyte
  • Ischemia-reperfusion
  • Myocardial infarction
  • Reproducibility
  • Rigor

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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