Replication protein A: Directing traffic at the intersection of replication and repair

Greg G. Oakley; Steve M. Patrick

doi:10.2741/3652

Replication protein A: Directing traffic at the intersection of replication and repair

Greg G. Oakley, Steve M. Patrick

Research output: Contribution to journal › Review article › peer-review

117 Scopus citations

Abstract

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.

Original language	English (US)
Pages (from-to)	883-900
Number of pages	18
Journal	Frontiers in Bioscience
Volume	15
Issue number	3
DOIs	https://doi.org/10.2741/3652
State	Published - Jun 1 2010

Keywords

Checkpoint activation
DNA damage response
DNA repair
DNA replication
Phosphorylation
RPA
Review

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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