Replication protein A: Directing traffic at the intersection of replication and repair

Greg G. Oakley, Steve M. Patrick

Research output: Contribution to journalReview article

113 Scopus citations

Abstract

Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.

Original languageEnglish (US)
Pages (from-to)883-900
Number of pages18
JournalFrontiers in Bioscience
Volume15
Issue number3
DOIs
StatePublished - Jun 1 2010

Keywords

  • Checkpoint activation
  • DNA damage response
  • DNA repair
  • DNA replication
  • Phosphorylation
  • RPA
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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