Reproductibilité et valeur pronostique des classifications histopathologiques des lymphomes malins. Prolégomènes pour une première classification internationale proposée par l'OMS

Translated title of the contribution: Reproducibility and prognostic value of the histopathologic classifications of malignant lymphomas. Introduction to the first international classification proposed by the WHO

Jacques Diebold, Dennis Weisenburger, Kenneth A. MacLennan, H. Konrad Müller-Hermelink, Bharat N. Nathwani, Nancy L. Harris, James R. Anderson, Pascal Roy, James O. Armitage

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Different histopathologic classifications have been used in the study of malignant lymphomas. The clinical relevance (reproducibility, prognostic value) has not been precisely studied. The « non-Hodgkin's lymphoma classification project » has been organized to study a cohort of I 403 cases in 9 sites around the world consisting of consecutive patients seen between 1988 and 1990 in order to have a good follow-up. The reproducibility of the up-dated Kiel and the ILSG (REAL) classifications between the 5 visiting expert hematopathologists was pretty good, at least 85 % for the majority of the entities. According to survival curves, the lymphomas can be statified in 4 different groups. Comparison with the international prognostic index demonstrate that for therapeutic strategy both histopathology and index should be used. The results bring a good support to the project of the WHO to propose the first international classification of lymphomas based on both forme classifications.

Translated title of the contributionReproducibility and prognostic value of the histopathologic classifications of malignant lymphomas. Introduction to the first international classification proposed by the WHO
Original languageFrench
Pages (from-to)1537-1549
Number of pages13
JournalBulletin de l'Academie Nationale de Medecine
Volume182
Issue number7
StatePublished - 1998

Keywords

  • Lymphoma, non-hodgkin, pathology
  • Lymphoma, nonhodgkin, classification
  • Prognosis
  • Survival analysis

ASJC Scopus subject areas

  • Medicine(all)

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