Research study designs: Non-experimental

Cheryl Bagley Thompson, Edward A. Panacek

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A core set of clinical research designs have stood the test of time and are repeatedly used in most studies. No single research design is best to answer all research questions, and every research design has appropriate applications. This and the previous articles have described the most common designs. However, in the process of performing research, there are always other options (Table 2), and "hybrid" studies combining elements from different designs are not uncommon. This article does not have sufficient space to discuss subtypes and hybrid designs. Although it is a good practice to think of research designs in terms of degree of scientific integrity or rigor, it must be recognized that every design type has both advantages and disadvantages. In addition, usually many different ways are available to answer the same research question. Which design is most appropriate depends largely on a stage of evolution of the investigative process and the resources available. An understanding of the full breadth and spectrum of research study designs is necessary to select the model that is most appropriate for a given investigation. In general, the best approach is to use the most scientifically valid design that the circumstances will allow. However, the actual decision regarding the design usually represents a compromise between lofty scientific goals and the clinical or resource limitations of the research setting. Therefore, be realistic about the resources available, including the time frame and finances. Realize that research is done in incremental steps, and it is unusual to be able to answer an entire important research question in a single study. The process of planning and revising the protocol, before starting the actual data collection, is critically important. The extra time spent planning will pay off in time savings during the actual study itself. Involvement of a statistician during the planning process, before collecting any data, also can be quite helpful. Once you have a sense of which research study design is most appropriate to answer your research question, the next step is to flesh out the actual research protocol itself. That process will be addressed in the next part of this series.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalAir medical journal
Issue number1
StatePublished - Jan 2007
Externally publishedYes

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency


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