Response of marmosets to experimental infection with Epstein Barr virus

F. Deinhardt, L. Falk, L. G. Wolfe, J. Paciga, D. Johnson

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10 Scopus citations

Abstract

The response of cotton tpped (CT0 or white lipped (WL) marmosets, inoculated with material containing Epstein Barr virus (EBV), was studied. Twenty five marmosets inoculated with 10 6-10 8 cells from human or simian EBV carrying lymphoblastoid cell cultures developed no detectable clinical disease. Transitory antibody titres to VCA were detected in sera from several of these marmosets. Thirtyeight marmosets inoculated with P3 virus (10 9 particles) and seven marmosets inoculated with 10 5 infectious units of HR 1 virus likewise developed no recognizable clinical or haematological disease over several years of observation. Fouteen marmosets were inoculated with 10 2-10 4 transforming units (TFU) of EBV strain B95-8; five of 11 animals inoculated with 10 3-10 4 TFU of virus developed malignant lymphoma and died 31-110 days PI. Antibodies to one or more EBV specified antigens were detected in sera from nine of the inoculated marmosets. EBV carrying lymphoblastoid cell cultures were established from the spleen and lymph nodes of one animal that died with malignant lymphoma and from another animal that died 19 days PI from undetermined causes.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalIARC (International Agency for Research on Cancer) Scientific Publications
VolumeNo.11 II
StatePublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

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