Response of tumors to therapy studied by31p magnetic resonance spectroscopy

G. S. Karczmar, D. J. Meyerhoff, A. Speder, F. Valone, M. Wilkinson, N. Shine, M. D. Boska, M. W. Weiner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D20, and in tumor adenosine triphosphate (ATP), measured by 31P magnetic resonance spectroscopy (MRS) following administration of TNF. The decrease in ATP generally followed reduction in tumor blood flow, and therefore was probably due to ischemia caused by damage to tumor vasculature. Superficial human tumors have been studied by MRS to characterize their 3IP spectra, and to measure metabolic changes during therapy. The ratio of the intensities of the phosphomonoester (PME) and ATP resonances (PME/ATP) was much higher in tumors than in the normal tissue displaced by the tumors. During therapy, decreases in PME/ATP were detected that paralleled, but did not anticipate, decreases in tumor size. In some cases, a transient increase in PME/ATP was detected during therapy, which did not correlate with changes in tumor size, and which may reflect stimulation of cell growth in some tumor zones.

Original languageEnglish (US)
Pages (from-to)1020-1023
Number of pages4
JournalInvestigative Radiology
Volume24
Issue number12
DOIs
StatePublished - Dec 1989

Keywords

  • P MRS
  • Tumor blood flow
  • Tumor metabolism
  • Tumor necrosis factor
  • Tumor therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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